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The body regulates intracellular GSH primarily through upregulating synthesis (via gamma-glutamylcysteine synthetase) rather than importing intact glutathione from circulation

45, 46 The labile ironsulfur (Fe-S) cluster present in the active site of aconitase is a major target of excessive mitochondrial superoxide

World Psychiatry 15 , 166174 (2016)

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Proc Natl Acad Sci USA 118:e2022756118 Saito K, Kratzat H, Campbell A, Buschauer R, Burroughs AM, Berninghausen O, Aravind L, Green R, Beckmann R, Buskirk AR (2022) Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria